Interaction network and enrichment analysis of genes downregulated in MIR517A OE
Canned Analysis
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General Information
AccessionDCA00038673
TitleInteraction network and enrichment analysis of genes downregulated in MIR517A OE
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between MIR517A OE cells and control cells in the Huh-7 hepatocellular carcinoma cell line transduced with lentivirus. GFP+ cells were sorted by fluorescence-activated cell sorting (FACS) analysis cell type.
Analysis URLhttp://genemania.org/#/search/human/GC|LYZ|CXCL2|SNHG3|CCT2|C3|GAPDH|HIST1H1B|RPLP2|HSPB1|SLC6A14|GPI|CCL20|RPS17|HIST1H2BM|CES1|KRTAP5-3|LOX|MDM2|P4HA1|ALDOC|DCXR|MDK|ATP10D|IGHG1
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorgszeto
CREEDS IDgene:2561
Cell TypeHuh-7 hepatocellular carcinoma cell line transduced with lentivirus. GFP+ cells were sorted by fluorescence-activated cell sorting (FACS) analysis
Gene Symbol (human)MIR517A
Organismhuman
Perturbation TypeOE
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM518632, GSM518633, GSM518634
Perturbed SamplesGSM518635, GSM518636, GSM518637
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE20679
Gene Expression Omnibus
mRNA expression profile modified by microRNA mir-517a (MIR517A) in human hepatocellular carcinoma cell line
7
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