Interaction network and enrichment analysis of genes upregulated in SIRT7 KO
Canned Analysis
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General Information
AccessionDCA00038712
TitleInteraction network and enrichment analysis of genes upregulated in SIRT7 KO
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most upregulated genes identified by applying the Characteristic Direction method comparing gene expression between SIRT7 KO cells and control cells in the liver cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Cyp4a14|Cyp4a31|LOC100504128|Egr1|Cyp2a5|Hbb-bs|Fasn|E430024C06Rik|Inmt|Serpina1b|Lpin1|Ttr|Rpl14-ps1|Elovl2|Fau|Gm19831|Gcgr|Cat|Abcc3|Hebp1|Dnase2a|Eef1b2|Amdhd1|Nr0b2|Cyp2c29
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorMicrotaskManic
CREEDS IDgene:2580
Cell Typeliver
Gene Symbol (human)SIRT7
Gene Symbol (mouse)Sirt7
Organismmouse
Perturbation TypeKO
Characteristic Direction parameters
Gene Setupregulated
Gene Set Size50
Control SamplesGSM1213632, GSM1213633, GSM1213634
Perturbed SamplesGSM1213635, GSM1213636, GSM1213637
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE50076
Gene Expression Omnibus
SIRT7 suppresses tumorigenesis by attenuating MYC activity
7
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