Interaction network and enrichment analysis of genes upregulated in PTEN KO
Canned Analysis
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General Information
AccessionDCA00038716
TitleInteraction network and enrichment analysis of genes upregulated in PTEN KO
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most upregulated genes identified by applying the Characteristic Direction method comparing gene expression between PTEN KO cells and control cells in the Regulatory T cells (Treg) cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Rnaset2b|S100a4|Ifi27l2a|Srgn|Rpl30|Ptprc|Trav9d-3|Lgals1|Tmsb4x|Ly6a|Rps18|S100a6|Ddit4|Sh2d1a|Fth1|Cd3g|Trpt1|Dusp1|Cxcr3|AW112010|5830469G19Rik|Rps27a|H3f3b|Bcl2a1a|Rpl26
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatormaroulisv
CREEDS IDgene:2582
Cell TypeRegulatory T cells (Treg)
Gene Symbol (human)PTEN
Gene Symbol (mouse)Pten
Organismmouse
Perturbation TypeKO
Characteristic Direction parameters
Gene Setupregulated
Gene Set Size50
Control SamplesGSM1554125, GSM1554126, GSM1554127
Perturbed SamplesGSM1554128, GSM1554129, GSM1554130
Tools used in the analysis
Keyword
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Datasets used in the analysis
Keyword
Tool Name
GSE63625
Gene Expression Omnibus
Regulatory T cells require the phosphatase PTEN to restrain type 1 and follicular helper T-cell responses
7
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