Interaction network and enrichment analysis of genes downregulated in CTNNB1 KO
Canned Analysis
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General Information
AccessionDCA00038717
TitleInteraction network and enrichment analysis of genes downregulated in CTNNB1 KO
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between CTNNB1 KO cells and control cells in the BxPC3 pancreatic adenocarcinoma cells cell type.
Analysis URLhttp://genemania.org/#/search/human/KRT13|IGFBP5|RPS6|CEACAM6|ALDH1A3|RN7SL1|PABPC1|TACSTD2|TNFRSF21|HSPA8|CAV1|KRT6A|H19|F3|LOC644936|TUBA1C|ACTN4|HNRNPD|ANXA2P2|MYH9|ANP32B|PRDX1|HIST1H4C|DCBLD2|SET
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatormaroulisv
CREEDS IDgene:2583
Cell TypeBxPC3 pancreatic adenocarcinoma cells
Gene Symbol (human)CTNNB1
Organismhuman
Perturbation TypeKO
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM1539909, GSM1539910, GSM1539911, GSM1539912, GSM1539913, GSM1539915
Perturbed SamplesGSM1539916, GSM1539917, GSM1539918, GSM1539919, GSM1539920, GSM1539921, GSM1539922, GSM1539923, GSM1539924, GSM1539925, GSM1539926, GSM1539927
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE63072
Gene Expression Omnibus
Global gene expression analysis comparing wild type and beta catenin deficient BxPC3 pancreatic adenocarcinoma cells.
7
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