Interaction network and enrichment analysis of genes downregulated in FLNB KO
Canned Analysis
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General Information
AccessionDCA00038735
TitleInteraction network and enrichment analysis of genes downregulated in FLNB KO
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between FLNB KO cells and control cells in the murine kidney, cystic epithelial tissue cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Dnase1|Pah|Miox|Cyp4b1|Fbp1|Kap|Egf|Hao2|Slc34a1|Aadat|Hsd3b4|Hbb-bs|Hpd|Slc27a2|Acadm|Ttc36|Ugt3a2|Gpx1|Cyp2e1|Gpx3|Aldob|Wfdc15b|Akr1c21|Fmo1|4931406C07Rik
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorgszeto
CREEDS IDgene:2596
Cell Typemurine kidney, cystic epithelial tissue
Gene Symbol (human)FLNB
Gene Symbol (mouse)Flnb
Organismmouse
Perturbation TypeKO
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM266130, GSM266131, GSM266132
Perturbed SamplesGSM266133, GSM266134, GSM266135
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE10989
Gene Expression Omnibus
Expression data of cystic renal epithelial tissue from mice deficient for fumarate hydratase.
7
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