Interaction network and enrichment analysis of genes downregulated in SOX2 KD
Canned Analysis
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General Information
AccessionDCA00038763
TitleInteraction network and enrichment analysis of genes downregulated in SOX2 KD
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between SOX2 KD cells and control cells in the mOS-482 cells cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Rpl39l|Magohb|Xist|Rhox5|Bgn|Zic1|Gm10128|Tgfbi|Hspa1b|Antxr2|AW209491|Dlx5|Sgk1|Reps1|Tceal8|Rnf128|Nrbf2|Ptpn9|LOC100504837|Pde12|Cd99|Lsm2|Zhx1|Nup153|Ccne2
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorlkwhite
CREEDS IDgene:2616
Cell TypemOS-482 cells
Gene Symbol (human)SOX2
Gene Symbol (mouse)Sox2
Organismmouse
Perturbation TypeKD
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM1585264, GSM1585265, GSM1585266
Perturbed SamplesGSM1585267, GSM1585268, GSM1585269
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE64965
Gene Expression Omnibus
Expression profile of osteosarcoma cells in which Sox2 maintains cancer stem cells
7
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