Interaction network and enrichment analysis of genes downregulated in FOXO3 KO
Canned Analysis
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General Information
AccessionDCA00038843
TitleInteraction network and enrichment analysis of genes downregulated in FOXO3 KO
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between FOXO3 KO cells and control cells in the forebrain cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Bnip3|Gpi1|Tpi1|Sparcl1|Ddit4|Apoe|Basp1|Gm9790|Pgam1|Ppp1r3c|BC094435|Gapdh|Ldha|Appl2|Sox2|Pgk1|Ero1l|Bsg|A2m|Mt2|Rps12|Vegfa|Chchd2|Fabp5|Sepp1
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorMicrotaskManic
CREEDS IDgene:2698
Cell Typeforebrain
Gene Symbol (human)FOXO3
Organismmouse
Perturbation TypeKO
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM457631, GSM457632, GSM457635, GSM457636
Perturbed SamplesGSM457629, GSM457630, GSM457633, GSM457634
Tools used in the analysis
Keyword
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Datasets used in the analysis
Keyword
Tool Name
GSE18326
Gene Expression Omnibus
Role of FoxO3 in adult neural stem cell maintenance in mice
7
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