Interaction network and enrichment analysis of genes upregulated in AIRE KO
Canned Analysis
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General Information
AccessionDCA00038878
TitleInteraction network and enrichment analysis of genes upregulated in AIRE KO
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most upregulated genes identified by applying the Characteristic Direction method comparing gene expression between AIRE KO cells and control cells in the Medullary thymic epithelial cells (with low CD80 expression) cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Mt2|Gsto1|Krt8|Anxa2|Sqstm1|Btg2|Ahnak|Gadd45b|Rela|Atf4|Cdcp1|Ybx1|Sgk1|Chil3|Eef1a1|Rpl3|Msln|Rac1|Fosb|Errfi1|Eif1|Lamc2|Cdkn1c|Cldn4|Nfkb1
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDgene:272
Cell TypeMedullary thymic epithelial cells (with low CD80 expression)
Gene Symbol (human)AIRE
Gene Symbol (mouse)Aire
Organismmouse
Perturbation TypeKO
Characteristic Direction parameters
Gene Setupregulated
Gene Set Size50
Control SamplesGSM49737, GSM49738
Perturbed SamplesGSM49733, GSM49734
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE2585
Gene Expression Omnibus
Transcription factor Aire deficiency effect on medullary thymic epithelial cells
14
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