Interaction network and enrichment analysis of genes downregulated in XBP1 KO
Canned Analysis
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General Information
AccessionDCA00038927
TitleInteraction network and enrichment analysis of genes downregulated in XBP1 KO
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between XBP1 KO cells and control cells in the spleen CD11b Dendritic cells cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Hba-a2|Hbb-bt|Hbb-b2|Ighv1-72|Itgb2|Gm12191|Ckb|Mdh2|Rps19|Xbp1|Gpi1|Rps29|Ly6e|S100a10|Igkv6-14|Rac2|Rnf130|Marveld1|Apoe|Apol7c|Rnase6|Naaa|Tmsb10|Cd37|Cd81
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorKathaLahl
CREEDS IDgene:2766
Cell Typespleen CD11b Dendritic cells
Gene Symbol (human)XBP1
Gene Symbol (mouse)Xbp1
Organismmouse
Perturbation TypeKO
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM1277096, GSM1277097, GSM1277098
Perturbed SamplesGSM1277099, GSM1277100, GSM1277101
Tools used in the analysis
Keyword
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Datasets used in the analysis
Keyword
Tool Name
GSE52857
Gene Expression Omnibus
Expression data in splenic DC subsets in wild type and Xbp1 deficient mice
14
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