Interaction network and enrichment analysis of genes downregulated in E2F8 KO
Canned Analysis
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General Information
AccessionDCA00039047
TitleInteraction network and enrichment analysis of genes downregulated in E2F8 KO
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between E2F8 KO cells and control cells in the spleen Ter19+CD71 cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Gdpd3|Cat|Fam46c|Cd74|Rnf10|Ube2o|Glrx|Fam213a|Gda|Cd79b|Bpgm|Aldh1a1|Xpo7|Srgn|Ube2h|Fam220a|Rb1|Rsad2|Ube2r2|Dcaf12|Ly6e|H2-Aa|Mkrn1|Snca|F830002L21Rik
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorTolen
CREEDS IDgene:2828
Cell Typespleen Ter19+CD71
Gene Symbol (human)E2F8
Gene Symbol (mouse)E2f8
Organismmouse
Perturbation TypeKO
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM1260396, GSM1260397, GSM1260398
Perturbed SamplesGSM1260399, GSM1260400, GSM1260401
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE52157
Gene Expression Omnibus
Expression data from WT, E2f8 KO, Rb KO and Rb;E2f8 DKO spleen Ter19+CD71high sorted cells
14
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