Interaction network and enrichment analysis of genes downregulated in BTK KO
Canned Analysis
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General Information
AccessionDCA00039055
TitleInteraction network and enrichment analysis of genes downregulated in BTK KO
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between BTK KO cells and control cells in the Splenic B-cells cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Iglc3|Iglc2|Faim3|LOC433053|Zfp526|Igj|Rps27a|H2-Eb1|Rplp2|Rps3a2|LOC100044627|Cd52|Tmsb4x|S100a8|Rpl31|Rpl10a|Rpl28|LOC630855|Rpl3|Ngp|Rpl39-ps|Rpl31-ps17|Rps6-ps4|Rps27rt|Plac8
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorTolen
CREEDS IDgene:2833
Cell TypeSplenic B-cells
Gene Symbol (human)BTK
Gene Symbol (mouse)Btk
Organismmouse
Perturbation TypeKO
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM1303878, GSM1303879
Perturbed SamplesGSM1303876, GSM1303877
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE53946
Gene Expression Omnibus
Affymetrix gene expression of Transitional Type-1 B-cells from Wild-type (CBA), Xid and Btk KO mice
7
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