Interaction network and enrichment analysis of genes upregulated in SOX10 KO
Canned Analysis
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General Information
AccessionDCA00039070
TitleInteraction network and enrichment analysis of genes upregulated in SOX10 KO
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most upregulated genes identified by applying the Characteristic Direction method comparing gene expression between SOX10 KO cells and control cells in the Schwannoma cell line. NB: This is actually a rat dataset, but I "chose" mouse because mouse is more similar to rats than man and there was no drop down option for Rattus norvegicus. cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Tagln|Myl9|Hist1h2bh|Timm8b|Fth1|Nsa2|Fbln2|Atp6v0d1|Arpc3|Ap2m1|Tomm7|Ptp4a1|Zwint|Tpm4|Loxl2|Fstl1|Chchd2|Ctgf|Atp5l|Ccng1|Atp6v1d|Ldha|Akap12|Uqcr10|Atp6v0e1
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatortpaunesku
CREEDS IDgene:284
Cell TypeSchwannoma cell line. NB: This is actually a rat dataset, but I "chose" mouse because mouse is more similar to rats than man and there was no drop down option for Rattus norvegicus.
Gene Symbol (human)SOX10
Gene Symbol (mouse)Sox10
Organismmouse
Perturbation TypeKO
Characteristic Direction parameters
Gene Setupregulated
Gene Set Size50
Control SamplesGSM303510, GSM303512
Perturbed SamplesGSM303507, GSM303511
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE12007
Gene Expression Omnibus
Sox10 depletion effect on Schwannoma cell line
7
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