Interaction network and enrichment analysis of genes downregulated in CD24 KD
Canned Analysis
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General Information
AccessionDCA00039073
TitleInteraction network and enrichment analysis of genes downregulated in CD24 KD
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between CD24 KD cells and control cells in the HT29 cell type.
Analysis URLhttp://genemania.org/#/search/human/TSPAN8|HSP90AA1|EIF3E|HSPD1|CD24|CALM2|UGT1A3|UGT1A1|EIF3H|B2M|EPCAM|TFRC|LDHB|YWHAZ|PTGES3|ANXA4|TCEA1|CCNG1|NCL|SDCBP|HNRNPA2B1|NPTN|SRP9|RPL34|LGALS4
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorApozar
CREEDS IDgene:2842
Cell TypeHT29
Gene Symbol (human)CD24
Organismhuman
Perturbation TypeKD
None{u'vals': [-0.0669983907165, -0.0645012802441, -0.0585908750106, -0.053863663988, -0.0528733563216, 0.0464822444043, 0.0462185112255, 0.0461017495122, -0.0442223030568, 0.0430079220061, 0.0422034622067, -0.0412612561461, -0.0408950205837, -0.0402695588483
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM377671, GSM377675
Perturbed SamplesGSM377676, GSM377677, GSM377678
Tools used in the analysis
Keyword
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Datasets used in the analysis
Keyword
Tool Name
GSE15102
Gene Expression Omnibus
Response of pancreatic and colorectal cancer cells to CD24 down-regulation by monoclonal antibody or small interfering RNA
7
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