Interaction network and enrichment analysis of genes downregulated in HDAC2 KO
Canned Analysis
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General Information
AccessionDCA00039075
TitleInteraction network and enrichment analysis of genes downregulated in HDAC2 KO
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between HDAC2 KO cells and control cells in the colon cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Reg4|Iglc3|Hspa1b|H2-L|Cfd|Adh1|Mptx1|LOC544903|Lpo|Igj|Spink3|Gm4076|Igkv8-30|Sepp1|Ggh|Retnlb|Adipoq|Hspa1a|Ang4|Cyp2e1|Cela1|Pigr|Gsto1|Sycn|Sval1
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorKathaLahl
CREEDS IDgene:2844
Cell Typecolon
Gene Symbol (human)HDAC2
Gene Symbol (mouse)Hdac2
Organismmouse
Perturbation TypeKO
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM1323977, GSM1323978, GSM1323979
Perturbed SamplesGSM1323980, GSM1323981, GSM1323982
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE54785
Gene Expression Omnibus
The acetylome regulators Hdac1 and Hdac2 differently modulate intestinal epithelial cell dependent homeostatic responses in experimental colitis
7
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