Interaction network and enrichment analysis of genes downregulated in PTEN KO
Canned Analysis
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General Information
AccessionDCA00039133
TitleInteraction network and enrichment analysis of genes downregulated in PTEN KO
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between PTEN KO cells and control cells in the MEF cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Col2a1|H19|Hist1h2ao|Ctgf|Igfbp2|Anxa3|Sqle|Cnn2|Pcna|Acat2|Scd2|Eif3f|Rpl39-ps|Zfp526|Rps27rt|Mgp|Tuba1a|Bmp4|Mest|Gm10260|Rps13|Fabp5|Rpl22l1|Gm10094|Gpc3
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatormauroccm
CREEDS IDgene:2880
Cell TypeMEF
Gene Symbol (human)PTEN
Gene Symbol (mouse)Pten
Organismmouse
Perturbation TypeKO
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM1568311, GSM1568312, GSM1568313, GSM1568314
Perturbed SamplesGSM1568323, GSM1568324, GSM1568325, GSM1568326
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE64302
Gene Expression Omnibus
Expression Data from PtenF341V and Null Mouse Embryonic Fibroblasts
7
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