Interaction network and enrichment analysis of genes downregulated in EPAS1 KD
Canned Analysis
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General Information
AccessionDCA00039137
TitleInteraction network and enrichment analysis of genes downregulated in EPAS1 KD
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between EPAS1 KD cells and control cells in the Human hepatocellular liver carcinoma cells (HepG2) cell type.
Analysis URLhttp://genemania.org/#/search/human/IGFBP1|MT2A|ACTG1|AKR1C2|SLC2A3|ENO1|TF|SLC2A1|LYZ|CP|GAPDH|DKK1|CCL20|IER3|TMSB10|FN1|RN7SK|P4HB|RPL8|GPX3|COX6A1|ARL6IP1|EPAS1|CTGF|RPL38
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorTolen
CREEDS IDgene:2882
Cell TypeHuman hepatocellular liver carcinoma cells (HepG2)
Gene Symbol (human)EPAS1
Gene Symbol (mouse)Epas1
Organismhuman
Perturbation TypeKD
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM1313768, GSM1313769, GSM1313770, GSM1313771
Perturbed SamplesGSM1313776, GSM1313777, GSM1313778, GSM1313779
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE54360
Gene Expression Omnibus
Genexpression profiling of wild type, HIF-1 knockdown, or HIF-2 knockdown HepG2 tumor spheroids
14
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