Interaction network and enrichment analysis of genes downregulated in HDAC2 KD
Canned Analysis
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General Information
AccessionDCA00039145
TitleInteraction network and enrichment analysis of genes downregulated in HDAC2 KD
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between HDAC2 KD cells and control cells in the Huh7 cell type.
Analysis URLhttp://genemania.org/#/search/human/AFP|EIF4A1|CDC20|PLIN3|AKR1C2|TGFBI|EBNA1BP2|LAIR1|YBX3|C1QBP|RPS2|HSP90B1|TUBA1C|PFN1|C20orf24|JTB|ENO1|SSU72|SOD1|NOP56|HSP90AA1|S100P|SRP9|SLC7A5|HMGCS1
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorApozar
CREEDS IDgene:2890
Cell TypeHuh7
Gene Symbol (human)HDAC2
Gene Symbol (mouse)Hdac2
Organismhuman
Perturbation TypeKD
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM1261609, GSM1261610, GSM1261611, GSM1261612
Perturbed SamplesGSM1261613, GSM1261614, GSM1261615, GSM1261616
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE52232
Gene Expression Omnibus
Effect of HDAC2 siRNA on HCC
7
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