Interaction network and enrichment analysis of genes upregulated in RPS6KA3 KO
Canned Analysis
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General Information
AccessionDCA00039160
TitleInteraction network and enrichment analysis of genes upregulated in RPS6KA3 KO
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most upregulated genes identified by applying the Characteristic Direction method comparing gene expression between RPS6KA3 KO cells and control cells in the primary murine fibroblast-like synoviocytes (FLS) cell type.
Analysis URLhttp://genemania.org/#/search/mouse/E430024C06Rik|Egr1|Postn|Tagln|Serpine1|Ctgf|Thbs1|Myl9|Sgk1|Hmox1|Gm3601|Ptgs2|Timp1|U90926|Mcpt8|Htra1|F3|Serpinb2|Thbs2|Plac8|Cnn2|Mmp13|Errfi1|Tpm4|Pla2g4a
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorHollyWoodland
CREEDS IDgene:2894
Cell Typeprimary murine fibroblast-like synoviocytes (FLS)
Gene Symbol (human)RPS6KA3
Gene Symbol (mouse)Rps6ka3
Organismmouse
Perturbation TypeKO
Characteristic Direction parameters
Gene Setupregulated
Gene Set Size50
Control SamplesGSM1279903, GSM1279904, GSM1279905
Perturbed SamplesGSM1279900, GSM1279901, GSM1279902
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE52992
Gene Expression Omnibus
Ribosomal S6 kinase 2 deficiency effect on TNF- transgenic model of inflammatory arthritis: fibroblast-like synoviocytes
7
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