Interaction network and enrichment analysis of genes upregulated in RUNX1 KO
Canned Analysis
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General Information
AccessionDCA00039166
TitleInteraction network and enrichment analysis of genes upregulated in RUNX1 KO
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most upregulated genes identified by applying the Characteristic Direction method comparing gene expression between RUNX1 KO cells and control cells in the mammary gland luminal epithelial cells cell type.
Analysis URLhttp://genemania.org/#/search/mouse/C3|Rbp1|Ctgf|Fabp5|Gm3601|Cytip|Slc5a8|Ubd|Lgals7|Fcgbp|Egln3|Rerg|Ogfrl1|Psat1|Nrep|Tgfb2|Gjb2|Slc7a5|Kcnn4|Sertad4|Thbs1|Tubb2b|Tuba1a|Adamts1|Flna
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorHollyWoodland
CREEDS IDgene:2899
Cell Typemammary gland luminal epithelial cells
Gene Symbol (human)RUNX1
Gene Symbol (mouse)Runx1
Organismmouse
Perturbation TypeKO
Characteristic Direction parameters
Gene Setupregulated
Gene Set Size50
Control SamplesGSM1148294, GSM1148295, GSM1148296
Perturbed SamplesGSM1148297, GSM1148298, GSM1148299
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE47375
Gene Expression Omnibus
Microarray expression profiling study of Runx1-null and wild type luminal mammary epithelial cells
7
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