Interaction network and enrichment analysis of genes downregulated in RAP1A KO
Canned Analysis
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General Information
AccessionDCA00039181
TitleInteraction network and enrichment analysis of genes downregulated in RAP1A KO
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between RAP1A KO cells and control cells in the HCT116 cell type.
Analysis URLhttp://genemania.org/#/search/human/TNNC1|SUSD2|SLC1A3|SLC2A3|KRT7|TM4SF18|RGS2|BMP4|MNS1|CEMIP|DDIT4L|TACSTD2|MYL2|AXIN2|PDGFC|FOXQ1|TMSB15A|TWIST1|CRABP2|SEMA3A|SOX4|SGCE|VASH2|TMEM173|ID2
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorHollyWoodland
CREEDS IDgene:2904
Cell TypeHCT116
Gene Symbol (human)RAP1A
Gene Symbol (mouse)Rap1a
Organismhuman
Perturbation TypeKO
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM1516754, GSM1516755, GSM1516756, GSM1516757, GSM1516758, GSM1516759
Perturbed SamplesGSM1516760, GSM1516761, GSM1516762, GSM1516763, GSM1516764, GSM1516765
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE61900
Gene Expression Omnibus
TALEN gene knockouts reveal no requirement for the shelterin protein Rap1 in telomere protection and length regulation
21
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