Interaction network and enrichment analysis of genes downregulated in ZNF658 KD
Canned Analysis
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General Information
AccessionDCA00039217
TitleInteraction network and enrichment analysis of genes downregulated in ZNF658 KD
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between ZNF658 KD cells and control cells in the Caco-2 cells (siRNA2 knockdown) cell type.
Analysis URLhttp://genemania.org/#/search/human/RPS12|RPS19|RPL19P12|NDUFA4|SNRPG|TMSB10|RPS25|RPS11|RPLP2|RPS10|RPL38|FASN|RPL27A|ZFAS1|TXN|KPNB1|RPL19|POMP|SLIRP|COX6C|TOMM7|CALM2|RPS27|COX8A|RPS3
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDgene:2924
Cell TypeCaco-2 cells (siRNA2 knockdown)
Gene Symbol (human)ZNF658
Gene Symbol (mouse)Zfp735
Organismhuman
Perturbation TypeKD
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM1436132, GSM1436133, GSM1436134
Perturbed SamplesGSM1436129, GSM1436130, GSM1436131
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE59385
Gene Expression Omnibus
The zinc finger protein ZNF658 regulates the transcription of genes involved in zinc homeostasis and affects ribosome biogenesis through the zinc tran...
14
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