Interaction network and enrichment analysis of genes downregulated in YAP1 KD
Canned Analysis
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General Information
AccessionDCA00039219
TitleInteraction network and enrichment analysis of genes downregulated in YAP1 KD
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between YAP1 KD cells and control cells in the MZ1774 human ccRCC cell line cell type.
Analysis URLhttp://genemania.org/#/search/human/GDF15|NDRG1|ITPR3|CYR61|DDIT4|CSTB|ACTB|SPP1|ANXA2P2|HIST1H4C|AKR1B10|TPI1|ADM|TKT|SHMT2|MRPS6|TGFBI|PRDX1|SLC7A5|ALDH1A1|PSAP|SCD|HSP90B1|NDUFA1|HSPA1A
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDgene:2927
Cell TypeMZ1774 human ccRCC cell line
Gene Symbol (human)YAP1
Gene Symbol (mouse)Yap1
Organismhuman
Perturbation TypeKD
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM1213264, GSM1213265, GSM1213266, GSM1213267
Perturbed SamplesGSM1213260, GSM1213261, GSM1213262, GSM1213263
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE50053
Gene Expression Omnibus
YAP conveys an invasive phenotype to clear cell renal cell carcinoma cell lines via endothelin-2
7
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