Interaction network and enrichment analysis of genes upregulated in SOX2 KO
Canned Analysis
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General Information
AccessionDCA00039254
TitleInteraction network and enrichment analysis of genes upregulated in SOX2 KO
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most upregulated genes identified by applying the Characteristic Direction method comparing gene expression between SOX2 KO cells and control cells in the NTera-2 human embryonal carcinoma cell line cell type.
Analysis URLhttp://genemania.org/#/search/human/WLS|PTCH1|FABP3|FST|PKDCC|ZFP36L2|FN1|SSBP2|PRTG|CITED2|CA11|FOXO4|SLC7A8|MAP1B|NME4|SNAI2|LAPTM4B|HSPB1|RBBP4|CNTFR|SLC7A3|GATSL2|SPARC|ATP2B4|MIR198
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDgene:2957
Cell TypeNTera-2 human embryonal carcinoma cell line
Gene Symbol (human)SOX2
Gene Symbol (mouse)Sox2
Organismhuman
Perturbation TypeKO
Characteristic Direction parameters
Gene Setupregulated
Gene Set Size50
Control SamplesGSM1431072, GSM1431073, GSM1431074
Perturbed SamplesGSM1431075, GSM1431076, GSM1431077
Tools used in the analysis
Keyword
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Datasets used in the analysis
Keyword
Tool Name
GSE59234
Gene Expression Omnibus
Gene expression data from SOX2 knock-out 2102Ep and NTera-2 human embryonal carcinoma cell lines
14
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