Interaction network and enrichment analysis of genes downregulated in NOTCH1 OE
Canned Analysis
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General Information
AccessionDCA00039255
TitleInteraction network and enrichment analysis of genes downregulated in NOTCH1 OE
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between NOTCH1 OE cells and control cells in the Prostate luminal epithelial cells cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Sbp|Pbsn|9530002B09Rik|Tgm4|Sbpl|A630095E13Rik|C1ra|Mmp7|Tspan1|Fam163b|Gsdma|Cd24a|Ren1|Ren2|Car2|C1s2|Neurl4|Zfp36l3|Degs2|Gata2|C1rb|Cldn8|Ms4a5|Akr1b3|Ehf
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDgene:2958
Cell TypeProstate luminal epithelial cells
Gene Symbol (human)NOTCH1
Gene Symbol (mouse)Notch1
Organismmouse
Perturbation TypeOE
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM1280856, GSM1280857, GSM1280858, GSM1280859
Perturbed SamplesGSM1280860, GSM1280861, GSM1280862
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE53036
Gene Expression Omnibus
Gene expression profiling of mouse prostate over-expressing the Notch1 intracellular domain.
7
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