Interaction network and enrichment analysis of genes downregulated in NME2 Induction
Canned Analysis
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General Information
AccessionDCA00039257
TitleInteraction network and enrichment analysis of genes downregulated in NME2 Induction
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between NME2 Induction cells and control cells in the A549 lung adenocarcinoma cell line cell type.
Analysis URLhttp://genemania.org/#/search/human/AKR1C4|ACTB|FAM115A|IGFBP4|ITPK1-AS1|TUBA1B|PDE4C|YWHAQ|SUMO2|IL18|ANXA2P2|PFN1|ACTG1|RPS28|FARSB|ITGB1|LILRB3|RPL13AP5|RN7SL1|CALM2|IL10|SNAR-A1|NME1-NME2|UQCRHL|ZNF674
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDgene:2959
Cell TypeA549 lung adenocarcinoma cell line
Gene Symbol (human)NME2
Gene Symbol (mouse)Nme2
Organismhuman
Perturbation TypeInduction
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM988172, GSM988173, GSM988174
Perturbed SamplesGSM988175, GSM988176, GSM988177
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE40194
Gene Expression Omnibus
Expression profile of lung adenocarcinoma, A549 cells following induction of non metastatic 2 (NME2/NM23 H2)
7
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