Interaction network and enrichment analysis of genes downregulated in HSPB8 KO
Canned Analysis
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General Information
AccessionDCA00039309
TitleInteraction network and enrichment analysis of genes downregulated in HSPB8 KO
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between HSPB8 KO cells and control cells in the Heart (left ventricles) cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Tcap|Rplp0|Neat1|Pdk4|Hspb8|1200016E24Rik|Herpud1|Txnip|Myl7|Mt2|Ddit4|Cox7a1|Atp5e|Cox6a2|Ech1|Cox4i1|Cox8b|Rps14|Gm5805|Rplp1|Ubc|Bnip3|Aqp1|Ly6c2|Dusp1
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorJuliana
CREEDS IDgene:2996
Cell TypeHeart (left ventricles)
Gene Symbol (human)HSPB8
Gene Symbol (mouse)Hspb8
Organismmouse
Perturbation TypeKO
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM603058, GSM603059, GSM603060
Perturbed SamplesGSM603061, GSM603062, GSM603063
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE24489
Gene Expression Omnibus
Effect of H11 Kinase/Hsp22 deletion in response to cardiac stress
7
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