Interaction network and enrichment analysis of genes downregulated in HDC KO
Canned Analysis
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General Information
AccessionDCA00039321
TitleInteraction network and enrichment analysis of genes downregulated in HDC KO
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between HDC KO cells and control cells in the myeloid-derived suppressor cell from colon tumor cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Wfdc21|Hist1h2ao|Cd177|Ltf|Ifitm6|Chil4|Hmgn2-ps1|Chil3|Lcn2|Camp|Zmpste24|Dstn|Anxa3|Arhgdib|Cd24a|C3|Ap3s1|Mettl9|Fpr2|Pglyrp1|Mmp8|Olfm4|Tuba1b|Sh3bgrl3|Serpinb1a
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorJuliana
CREEDS IDgene:3002
Cell Typemyeloid-derived suppressor cell from colon tumor
Gene Symbol (human)HDC
Gene Symbol (mouse)Hdc
Organismmouse
Perturbation TypeKO
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM575708, GSM575709
Perturbed SamplesGSM575710, GSM575711
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE23502
Gene Expression Omnibus
Differentially expressed genes of CD11b+Gr-1+ myeloid cells
14
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