Interaction network and enrichment analysis of genes downregulated in STK11 KO
Canned Analysis
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General Information
AccessionDCA00039323
TitleInteraction network and enrichment analysis of genes downregulated in STK11 KO
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between STK11 KO cells and control cells in the LSK cell population (FACS sorted from bone marrow) cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Ngp|S100a8|Chil3|S100a9|Lcn2|Zfp526|Rps28|Gdpd3|Rpl39-ps|Camp|Ltf|Rpl13|Anxa1|Rps10|H2-Q7|Epc1|Rpl23a|Greb1|Gm1821|Itih5|F2r|Car2|Hlf|LOC100503721|Chchd2
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorJuliana
CREEDS IDgene:3003
Cell TypeLSK cell population (FACS sorted from bone marrow)
Gene Symbol (human)STK11
Gene Symbol (mouse)Stk11
Organismmouse
Perturbation TypeKO
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM609944, GSM609945, GSM609946
Perturbed SamplesGSM609940, GSM609941, GSM609942, GSM609943
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE24765
Gene Expression Omnibus
Gene expression profiles of Lkb1 WT and KO hematopoietic stem cells (HSCs)
7
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