Interaction network and enrichment analysis of genes downregulated in DBI KO
Canned Analysis
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General Information
AccessionDCA00039325
TitleInteraction network and enrichment analysis of genes downregulated in DBI KO
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between DBI KO cells and control cells in the Liver (21 day old mice) cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Dbi|Hamp|Sqle|H19|Hmgcs1|H2-Q10|Hbb-bs|Tuba1b|Idi1|Itih2|Gm3601|Ppia|Hba-a2|Fasn|Acsl5|Mbl2|Cyp2c68|Elovl5|Cyp2f2|Serpinf2|Agxt|Neat1|Hao2|Apcs|Plg
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorJuliana
CREEDS IDgene:3004
Cell TypeLiver (21 day old mice)
Gene Symbol (human)DBI
Gene Symbol (mouse)Dbi
Organismmouse
Perturbation TypeKO
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM602521, GSM602522, GSM602523
Perturbed SamplesGSM602524, GSM602525, GSM602526
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE24451
Gene Expression Omnibus
Knockout of the Acyl CoA binding protein (ACBP) in mice - expression profile from the liver of 21 days old ACBP-/- and +/+ mice.
7
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