Interaction network and enrichment analysis of genes downregulated in TCF7 KO
Canned Analysis
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General Information
AccessionDCA00039335
TitleInteraction network and enrichment analysis of genes downregulated in TCF7 KO
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between TCF7 KO cells and control cells in the CD8 memory T-cell cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Snord104|Xist|Eef1a1|Hsp90ab1|Rps20|Rps28|Mir682|Rps14|Uba52|Rplp0|Snord14e|Rps15|Rpl35|Rps5|Gnb2l1|Rps16-ps2|Hspa8|Rpl26|Rps26|Rps18|Rpl18a|Rpl13a|Snrpd3|Gm8580|Rpl4
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorJuliana
CREEDS IDgene:3010
Cell TypeCD8 memory T-cell
Gene Symbol (human)TCF7
Organismmouse
Perturbation TypeKO
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM520717, GSM520718, GSM520719
Perturbed SamplesGSM520720, GSM520721, GSM520722
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE20754
Gene Expression Omnibus
Expression data from WT and TCF-1-deficient memory CD8 T cells
7
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