Interaction network and enrichment analysis of genes downregulated in LRP5 KO
Canned Analysis
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General Information
AccessionDCA00039379
TitleInteraction network and enrichment analysis of genes downregulated in LRP5 KO
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between LRP5 KO cells and control cells in the osteoblasts (7 days) cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Rps12|Rpl9|Cstb|Hspa8|Ubb|Atpif1|Rps7|Rps27l|Myl6|Tmsb4x|Rps21|Rpl39|Rpl28|Rnu6|Gm1821|Atp5j2|Hnrnpab|Sqstm1|Lgals3|Cd164|Tpm1|Rps6|Npm1|Rps16|Rps8
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatormaroulisv
CREEDS IDgene:3042
Cell Typeosteoblasts (7 days)
Gene Symbol (human)LRP5
Gene Symbol (mouse)Lrp5
Organismmouse
Perturbation TypeKO
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM1348211, GSM1348213, GSM1348215, GSM1348217
Perturbed SamplesGSM1348210, GSM1348212, GSM1348214, GSM1348216
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE55900
Gene Expression Omnibus
Low-density lipoprotein receptor-5 contributes to whole body metabolism by regulating fatty acid metabolism in the osteoblast
7
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