Interaction network and enrichment analysis of genes upregulated in IFNAR1 Stimulation of gene product
Canned Analysis
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General Information
AccessionDCA00039418
TitleInteraction network and enrichment analysis of genes upregulated in IFNAR1 Stimulation of gene product
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most upregulated genes identified by applying the Characteristic Direction method comparing gene expression between IFNAR1 Stimulation of gene product cells and control cells in the Analysis of PBMCs from patients with clinically isolated syndrome suggestive of multiple sclerosis (CIS) cell type.
Analysis URLhttp://genemania.org/#/search/human/CCL3L3|APOBEC3A|NFKBIA|FOS|CXCL8|IFI44L|TRIM22|IFITM3|ISG15|CMPK2|IFIT3|ZFP36|IFIT1|PLAC8|IER2|IFITM1|IFITM2|MX1|LAP3|IFI30|TUBA1A|CD69|CD83|SGK1|KLF10
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorVICENTE
CREEDS IDgene:3061
Cell TypeAnalysis of PBMCs from patients with clinically isolated syndrome suggestive of multiple sclerosis (CIS)
Gene Symbol (human)IFNAR1
Gene Symbol (mouse)Ifnar1
Organismhuman
Perturbation TypeStimulation of gene product
Characteristic Direction parameters
Gene Setupregulated
Gene Set Size50
Control SamplesGSM1299335, GSM1299337, GSM1299339, GSM1299341, GSM1299343, GSM1299345
Perturbed SamplesGSM1299336, GSM1299338, GSM1299340, GSM1299342, GSM1299344, GSM1299346
Tools used in the analysis
Keyword
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Datasets used in the analysis
Keyword
Tool Name
GSE53716
Gene Expression Omnibus
IFN-1a in vivo treatment effect on CIS multiple sclerosis patients: peripheral blood mononuclear cells
7
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