Interaction network and enrichment analysis of genes downregulated in STAT3 Actvation of gene product
Canned Analysis
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General Information
AccessionDCA00039421
TitleInteraction network and enrichment analysis of genes downregulated in STAT3 Actvation of gene product
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between STAT3 Actvation of gene product cells and control cells in the Liver cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Gstp1|Cth|Got1|Cyp3a25|Gnmt|Hpd|Gm5424|Pah|Cyp3a59|Cps1|Slc7a2|Insig2|Hal|Etnppl|Tdo2|Asl|Cyp1a2|Cyp4a31|Herpud1|Pck1|Arg1|G6pc|Mfsd2a|Ahcy|Arrdc3
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorVICENTE
CREEDS IDgene:3063
Cell TypeLiver
Gene Symbol (human)STAT3
Gene Symbol (mouse)Stat3
Organismmouse
Perturbation TypeActvation of gene product
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM526561, GSM526562, GSM526602
Perturbed SamplesGSM526603, GSM526605, GSM526678
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE21060
Gene Expression Omnibus
Interleukin 6 effect on liver
7
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