Interaction network and enrichment analysis of genes downregulated in BTK KO
Canned Analysis
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General Information
AccessionDCA00039517
TitleInteraction network and enrichment analysis of genes downregulated in BTK KO
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between BTK KO cells and control cells in the splenic B cells cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Igkv6-23|Rpl41|Iglc3|Cd79b|Eef1a1|Rpl13|H2-Aa|Gm12191|Tpt1|Rplp0|Rps27rt|Cd74|Rps23|Cd79a|Gm10260|Rps12|Gm16409|Rpl34|Ltb|Cd19|Rps3|Rpl5|Rps11|Igkv6-15|H2-Eb1
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorantons
CREEDS IDgene:329
Cell Typesplenic B cells
Gene Symbol (human)BTK
Gene Symbol (mouse)Btk
Organismmouse
Perturbation TypeKO
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM61837, GSM61838
Perturbed SamplesGSM61841, GSM61842
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE2826
Gene Expression Omnibus
Bruton's tyrosine kinase mutant models of X-linked agammaglobulinemia
14
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