Interaction network and enrichment analysis of genes upregulated in PIN1 DEPLETION
Canned Analysis
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General Information
AccessionDCA00039674
TitleInteraction network and enrichment analysis of genes upregulated in PIN1 DEPLETION
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most upregulated genes identified by applying the Characteristic Direction method comparing gene expression between PIN1 DEPLETION cells and control cells in the MDA-MB-231 breast cancer cells cell type.
Analysis URLhttp://genemania.org/#/search/human/ANKRD1|CAV1|FTL|ATP1B1|KRT18|TSPAN8|S100A4|TIMP3|DPYSL2|LGALS3|CD55|AKR1B1|SLC38A2|SPINK4|DKK1|OPN3|F3|ARL6IP5|MORF4L2|BMP4|PRSS23|ADAM9|TXNRD1|HIST1H2BK|MORC4
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDgene:477
Cell TypeMDA-MB-231 breast cancer cells
Gene Symbol (human)PIN1
Gene Symbol (mouse)Pin1
Organismhuman
Perturbation TypeDEPLETION
Characteristic Direction parameters
Gene Setupregulated
Gene Set Size50
Control SamplesGSM645041, GSM645042, GSM645043
Perturbed SamplesGSM645038, GSM645039, GSM645040
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE26262
Gene Expression Omnibus
Mutant-p53 and Pin1 depleted MDA-MB-231 breast cancer cells
14
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