Interaction network and enrichment analysis of genes downregulated in MIR222 KD
Canned Analysis
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General Information
AccessionDCA00039683
TitleInteraction network and enrichment analysis of genes downregulated in MIR222 KD
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between MIR222 KD cells and control cells in the MCF7 breast cancer cells (fulvestrant-resistant) cell type.
Analysis URLhttp://genemania.org/#/search/human/RPL8|AKR1B10|S100P|S100A9|RPL34|NDUFA1|S100A7|IER3|SH3KBP1|H19|GADD45A|C20orf24|IFITM2|NFKBIA|SLC25A6|SNHG1|MSRB1|FTH1|SLC7A5|NQO1|MYO5C|FTL|LOC728026|RPL36|GARS
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDgene:483
Cell TypeMCF7 breast cancer cells (fulvestrant-resistant)
Gene Symbol (human)MIR222
Organismhuman
Perturbation TypeKD
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM493918, GSM493919, GSM493920
Perturbed SamplesGSM493924, GSM493925, GSM493926
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE19777
Gene Expression Omnibus
microRNA-221/222 knockdown effect on fulvestrant-resistant MCF7 breast cancer cells
14
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