Interaction network and enrichment analysis of genes upregulated in PPARA agonist activation
Canned Analysis
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General Information
AccessionDCA00039698
TitleInteraction network and enrichment analysis of genes upregulated in PPARA agonist activation
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most upregulated genes identified by applying the Characteristic Direction method comparing gene expression between PPARA agonist activation cells and control cells in the Isolated hepatocytes cell type.
Analysis URLhttp://genemania.org/#/search/human/ANGPTL4|ACSL1|CYP3A5|AADAC|AKR1C3|FABP1|HADHB|CCL20|VNN1|APOA2|ACADVL|AKR1B10|HERPUD1|UGT1A1|POR|ALAS1|UGT1A3|ETFA|GADD45A|PANK1|KLF10|ISCA1|PSMA6|MIR21|NNMT
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatordsurujon
CREEDS IDgene:501
Cell TypeIsolated hepatocytes
Gene Symbol (human)PPARA
Gene Symbol (mouse)Ppara
Organismhuman
Perturbation Typeagonist activation
Characteristic Direction parameters
Gene Setupregulated
Gene Set Size50
Control SamplesGSM432140, GSM432142, GSM432144, GSM432146, GSM432148, GSM432150, GSM432152, GSM432154, GSM432156, GSM432158, GSM432160, GSM432162
Perturbed SamplesGSM432139, GSM432141, GSM432143, GSM432145, GSM432147, GSM432149, GSM432151, GSM432153, GSM432155, GSM432157, GSM432159, GSM432161
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE17251
Gene Expression Omnibus
Comparative analysis of gene regulation by the transcription factor PPAR_human
7
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