Interaction network and enrichment analysis of genes downregulated in PML KO
Canned Analysis
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General Information
AccessionDCA00039729
TitleInteraction network and enrichment analysis of genes downregulated in PML KO
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between PML KO cells and control cells in the liver cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Bhmt|Cyp2a5|Thrsp|Serpina1a|Adh1|Ces1d|Gpx1|Acaa1b|Plin2|Cyp2c70|Inmt|AI195470|Car3|Aldh1a1|Arrdc3|Por|Fabp1|G0s2|Acox1|Hrg|Cpt1a|Gm19588|Apoc3|Ttpa|Fabp5
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatordsurujon
CREEDS IDgene:537
Cell Typeliver
Gene Symbol (human)PML
Gene Symbol (mouse)Pml
Organismmouse
Perturbation TypeKO
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM958302, GSM958306, GSM958307
Perturbed SamplesGSM958308, GSM958309, GSM958310
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE39220
Gene Expression Omnibus
High fat diet effect on liver depleted of promyelocytic leukemia gene
7
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