Interaction network and enrichment analysis of genes downregulated in CLDN18 KO
Canned Analysis
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General Information
AccessionDCA00039755
TitleInteraction network and enrichment analysis of genes downregulated in CLDN18 KO
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between CLDN18 KO cells and control cells in the whole lung tissue cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Egr1|Dusp1|Ly6a|Dnajb1|Errfi1|Cldn18|Sgk1|Tmem100|Aldh2|Chil1|Lor|Klf2|Ifitm3|Plvap|Gpx3|Ehd4|Ctgf|Aqp1|Tspan7|Fmo1|Ifitm2|F2r|Cav1|S100a9|Timp2
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorudicuty
CREEDS IDgene:55
Cell Typewhole lung tissue
Gene Symbol (human)CLDN18
Gene Symbol (mouse)Cldn18
Organismmouse
Perturbation TypeKO
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM1178814, GSM1178815, GSM1178816, GSM1178817
Perturbed SamplesGSM1178811, GSM1178812, GSM1178813
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE48443
Gene Expression Omnibus
Claudin 18 deficiency effect on the lung
7
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