Interaction network and enrichment analysis of genes downregulated in KLF5 KO
Canned Analysis
FAIR Metrics
0 evaluations
General Information
AccessionDCA00039781
TitleInteraction network and enrichment analysis of genes downregulated in KLF5 KO
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between KLF5 KO cells and control cells in the ES cells cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Hspb1|Zscan4a|U2af1|Mt2|Gm4340|Ldha|L1td1|Rpl36a|Pnp|Anp32b|Msh6|Ranbp1|Tipin|Pcna|BC094435|Ifitm1|Nedd4|Srsf5|Chchd10|Mrfap1|Stmn2|Hmces|Ptma|Gsta4|Rbbp7
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorvmathur
CREEDS IDgene:580
Cell TypeES cells
Gene Symbol (human)KLF5
Gene Symbol (mouse)Klf5
Organismmouse
Perturbation TypeKO
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM234772, GSM234773
Perturbed SamplesGSM234774, GSM234775
Tools used in the analysis
Keyword
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Datasets used in the analysis
Keyword
Tool Name
GSE9244
Gene Expression Omnibus
Transcription factor Klf5 deficiency effect on embryonic stem cells
7
FAIR Evaluation
Sorry, you must be signed in to evaluate this object.