Interaction network and enrichment analysis of genes downregulated in SP3 Deficiency
Canned Analysis
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General Information
AccessionDCA00039867
TitleInteraction network and enrichment analysis of genes downregulated in SP3 Deficiency
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between SP3 Deficiency cells and control cells in the Embryonic heart (day 12.5 C57Bl/6) cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Gm4076|Car2|Rpl39-ps|Ahsp|Alb|Prdx2|Pcna|Serpina1b|Apoa1|Blvrb|Dek|Gstp1|Serpina6|Nme2|Rrm2|Bex1|Sp3|Gm5805|Hmbs|Erh|Snrpe|Nme1|Acp5|Rplp0|Ftl2
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDgene:637
Cell TypeEmbryonic heart (day 12.5 C57Bl/6)
Gene Symbol (human)SP3
Gene Symbol (mouse)Sp3
Organismmouse
Perturbation TypeDeficiency
None{u'vals': [-0.0453292510202, -0.0423567648372, 0.0413601243931, -0.0409552186474, -0.0385082422312, -0.0375784412915, -0.0368527732649, 0.0365370621547, 0.0361261933007, -0.0359494945356, -0.0358988992464, 0.0351522132859, 0.0346144120186, 0.0344866717076
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM230957, GSM230959, GSM230960
Perturbed SamplesGSM230954, GSM230955, GSM230956
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE9124
Gene Expression Omnibus
Transcription factor Sp3 deficiency effect on the embryonic heart
7
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