Interaction network and enrichment analysis of genes downregulated in PPARA KO
Canned Analysis
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General Information
AccessionDCA00039895
TitleInteraction network and enrichment analysis of genes downregulated in PPARA KO
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between PPARA KO cells and control cells in the Small intestine cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Fabp1|Igkv8-30|Defa24|Fabp2|LOC544903|Defa-rs1|Actg1|Sprr2a2|Actb|Acaa1b|Chchd2|Igj|Dnase1|Itln1|Gpx2|Retsat|Adh1|Nfe2l2|Slc27a2|Gm15315|Neat1|Gzma|Cyp2c65|Ada|Rbp2
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorshvetank
CREEDS IDgene:981
Cell TypeSmall intestine
Gene Symbol (human)PPARA
Gene Symbol (mouse)Ppara
Organismmouse
Perturbation TypeKO
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM124308, GSM124309, GSM124310, GSM154798, GSM154799, GSM154800
Perturbed SamplesGSM124314, GSM124315, GSM124316, GSM154795, GSM154796, GSM154797
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE6864
Gene Expression Omnibus
PPARalpha deficient small intestine response to fasting
14
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