Interaction network and enrichment analysis of genes downregulated in CREB1 DEPLETION
Canned Analysis
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General Information
AccessionDCA00039931
TitleInteraction network and enrichment analysis of genes downregulated in CREB1 DEPLETION
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between CREB1 DEPLETION cells and control cells in the K562 myeloid leukemia cell line cell type.
Analysis URLhttp://genemania.org/#/search/human/HBZ|MRFAP1|H2BFS|HIST1H1C|HIST1H2BK|RPL8|ACSM3|EIF3E|HMGCS1|HBA2|PSAT1|CCNG1|PRKAR2B|LOC728026|GSTP1|HIST1H2AC|HIST2H2AA4|PTMA|ARL6IP1|CD164|RAN|HIST1H2BF|PSAP|RHAG|PPA1
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDgene:68
Cell TypeK562 myeloid leukemia cell line
Gene Symbol (human)CREB1
Gene Symbol (mouse)Creb1
Organismhuman
Perturbation TypeDEPLETION
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM304303, GSM304304, GSM304479, GSM304480, GSM304481, GSM304482, GSM304483, GSM304484, GSM304486, GSM304498
Perturbed SamplesGSM304487, GSM304488, GSM304489, GSM304490, GSM304491, GSM304492, GSM304493, GSM304494, GSM304495, GSM304496
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE12056
Gene Expression Omnibus
Transcription factor CREB depletion effect on myeloid leukemic cell line
7
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