Interaction network and enrichment analysis of genes downregulated in ADNP Deficiency - NULL MUTATION
Canned Analysis
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General Information
AccessionDCA00039971
TitleInteraction network and enrichment analysis of genes downregulated in ADNP Deficiency - NULL MUTATION
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between ADNP Deficiency - NULL MUTATION cells and control cells in the E9 embryos - Heterozygous mutant cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Rpl4|Hba-x|Eef1a1|Rps2-ps6|Rpl3|Kxd1|Rps12|Rpl6|Ino80|Rps3a2|Rps5|Rplp0|Rps2|Zfp526|Rps23|Ptma|Rpl27a|Rps11|Hbb-bh1|2810417H13Rik|Rps6-ps4|Rpl23a|Hist1h2ao|Gapdh|Rpl38
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDgene:718
Cell TypeE9 embryos - Heterozygous mutant
Gene Symbol (human)ADNP
Gene Symbol (mouse)Adnp
Organismmouse
Perturbation TypeDeficiency - NULL MUTATION
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM92912, GSM92922
Perturbed SamplesGSM92929, GSM92935, GSM92939
Tools used in the analysis
Keyword
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Datasets used in the analysis
Keyword
Tool Name
GSE4068
Gene Expression Omnibus
Activity-dependent neuroprotective protein null mutation effect on embryos
7
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