Interaction network and enrichment analysis of genes downregulated in HDAC9 INHIBITION - trichostatin A
Canned Analysis
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General Information
AccessionDCA00039979
TitleInteraction network and enrichment analysis of genes downregulated in HDAC9 INHIBITION - trichostatin A
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between HDAC9 INHIBITION - trichostatin A cells and control cells in the Endothelial cells cell type.
Analysis URLhttp://genemania.org/#/search/human/PECAM1|VWF|RPS19|CD93|FABP5|GSTO1|CD63|HSPB1|RPL13A|TMSB10|HSPA8|MARCKSL1|HSPG2|GLTSCR2|IFITM2|RPS11|RPS29|TAX1BP3|CLDN5|IGFBP4|SERPINH1|ITGA5|RHOC|EFNB2|RPL22
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDgene:736
Cell TypeEndothelial cells
Gene Symbol (human)HDAC9
Gene Symbol (mouse)Hdac9
Organismhuman
Perturbation TypeINHIBITION - trichostatin A
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM136682, GSM136696, GSM136697
Perturbed SamplesGSM136698, GSM136700, GSM136702
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE5856
Gene Expression Omnibus
Histone deacetylase inhibitor effect on endothelial cells
7
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