Interaction network and enrichment analysis of genes upregulated in HIF1A NULL MUTATION
Canned Analysis
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General Information
AccessionDCA00040011
TitleInteraction network and enrichment analysis of genes upregulated in HIF1A NULL MUTATION
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most upregulated genes identified by applying the Characteristic Direction method comparing gene expression between HIF1A NULL MUTATION cells and control cells in the Hepatocytes cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Rps19|Slc25a15|Apoc4|Mtch2|Fgb|Ndufb5|Apcs|Pah|Serpinb6a|Romo1|Actn4|Glrx3|Trp53inp2|Fam134b|Zfp36l1|Mgst1|Hspa5|Gstk1|Uqcrb|Myh9|Rnf11|Psma7|Cyp3a13|Ddit4|Itih3
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDgene:791
Cell TypeHepatocytes
Gene Symbol (human)HIF1A
Gene Symbol (mouse)Hif1a
Organismmouse
Perturbation TypeNULL MUTATION
Characteristic Direction parameters
Gene Setupregulated
Gene Set Size50
Control SamplesGSM21756, GSM21757
Perturbed SamplesGSM21754, GSM21755
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE1321
Gene Expression Omnibus
Hypoxia effect on HIF-1 alpha null hepatocytes
7
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