Interaction network and enrichment analysis of genes downregulated in PARK2 OE
Canned Analysis
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General Information
AccessionDCA00040038
TitleInteraction network and enrichment analysis of genes downregulated in PARK2 OE
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between PARK2 OE cells and control cells in the U87MG cell type.
Analysis URLhttp://genemania.org/#/search/human/ACTA2|HIST1H3I|LGALS1|RPL3|COL1A2|TUBB|MYL6|RN7SL2|GNB2L1|AHNAK2|ACTN1|SERPINE1|DAD1|CCND1|MYH9|ACTG1|FUT8|WDR1|SPP1|RN7SK|EDIL3|C14orf23|SLC7A8|CORO1C|MTHFD1
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorvirginia
CREEDS IDgene:82
Cell TypeU87MG
Gene Symbol (human)PARK2
Gene Symbol (mouse)Park2
Organismhuman
Perturbation TypeOE
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM729727, GSM729728, GSM729729, GSM729730, GSM729731, GSM729732, GSM729733, GSM729734, GSM729735, GSM729736, GSM729737, GSM729738
Perturbed SamplesGSM729739, GSM729740, GSM729741, GSM729742, GSM729743, GSM729744, GSM729745, GSM729746, GSM729747
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE29494
Gene Expression Omnibus
Parkin expression in parkin-deficient U87MG glioma cells
7
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