Interaction network and enrichment analysis of genes downregulated in MIR1-2 KO
Canned Analysis
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General Information
AccessionDCA00040048
TitleInteraction network and enrichment analysis of genes downregulated in MIR1-2 KO
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between MIR1-2 KO cells and control cells in the cardiac and skeletal muscle cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Nppb|Nppa|Csrp3|Ckmt2|Pdk4|Xist|Actc1|Cox7a1|Acadm|Mdh2|Acta1|Myl7|Tuba1b|Hspb6|Gm3150|Atp5g3|LOC100505088|Lpl|Uqcrc1|Rps2-ps6|Ndrg4|Nme2|Mybpc3|Rps2|Chchd10
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatormtahay
CREEDS IDgene:825
Cell Typecardiac and skeletal muscle
Gene Symbol (human)MIR1-2
Organismmouse
Perturbation TypeKO
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM176756, GSM176758, GSM176759
Perturbed SamplesGSM176757, GSM176760, GSM176761
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE7333
Gene Expression Omnibus
miRNA-1-2 knockout effect on the heart
7
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