Interaction network and enrichment analysis of genes downregulated in SRF NULL MUTATION
Canned Analysis
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General Information
AccessionDCA00040060
TitleInteraction network and enrichment analysis of genes downregulated in SRF NULL MUTATION
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between SRF NULL MUTATION cells and control cells in the Neonatal cardiomyocytes cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Tnnc1|Myh7|Actc1|Nppb|Myl3|Ankrd1|Nppa|Myl9|Fhl1|Ptpla|Myl2|Myom1|Tagln|Gm5526|Gm8894|Asb2|Popdc2|Tpm4|Fhl2|Smpx|Dstn|Srl|Casq1|Ehd4|Casq2
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDgene:851
Cell TypeNeonatal cardiomyocytes
Gene Symbol (human)SRF
Gene Symbol (mouse)Srf
Organismmouse
Perturbation TypeNULL MUTATION
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM71592, GSM71606, GSM71608
Perturbed SamplesGSM71610, GSM71612, GSM71613
Tools used in the analysis
Keyword
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Datasets used in the analysis
Keyword
Tool Name
GSE3181
Gene Expression Omnibus
Serum response factor null mutation effect on neonatal cardiomyocytes
7
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