Enrichment analysis of genes downregulated following Lubiprostone treatment
Canned Analysis
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General Information
AccessionDCA00055628
TitleEnrichment analysis of genes downregulated following Lubiprostone treatment
DescriptionAn enrichment analysis was performed on the top 500 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between Lubiprostone treated cells and untreated control cells.
Analysis URLhttp://amp.pharm.mssm.edu/Enrichr/enrich?dataset=1bv30
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorAxel
CREEDS IDdrug:2778
Drug NameLubiprostone
DrugBank IDDB01046
Organismmouse
PubChem CID656719
SMILES IDCCCCC(C1(CCC2C(O1)CC(=O)C2CCCCCCC(=O)O)O)(F)F
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size500
Control SamplesGSM457637, GSM457639
Perturbed SamplesGSM457638, GSM457640
Tools used in the analysis
Keyword
Dataset Accession
Enrichr
Published May 2016
A comprehensive gene set enrichment analysis web server 2016 update
7759
65
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE18327
Gene Expression Omnibus
Lubiprostone effect on cystic fibrosis small intestine phenotype
7
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